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Preliminary Studies Utilizing a New Flat Retina Technique

ROBERT KIRSCHNER, M.D.; IRVING H. LEOPOLD, M.D.

Arch Ophthalmol. 1960;64(5):681-684.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The recent advances clarifying the role of lipid metabolism in diabetes have produced a resurgence of interest in the study of experimental retinopathy.

Ashton¹ states that true diabetic retinopathy has never been produced in the laboratory animal. The experiments of Becker² utilizing alloxanized rabbits receiving corticotropin (ACTH) could not be duplicated by Marble³ and others.

Unequivocal aneurysmal changes have been demonstrated experimentally in the cat by induced retinal venous thrombosis, not by the metabolic alterations of diabetes alone.⁴

Microaneurysms may be seen in many disease states,⁵ and occur randomly in normal preparations of rabbit and human retina. For these reasons a more exact criterion of what constitutes early pathognomonic change in the retinal capillary is a necessity for future animal experimentation.

The literature is replete with methods for flat retina preparation, but only a few techniques have been widely applied.^6-13 The popular Hotchkiss-McManus technique . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Graduate School of Medicine University of Pennsylvania and the Research Department of the Wills Eye Hospital.

Footnotes
Submitted for publication Aug. 17, 1960.

Presented at Section of Ophthalmology, College of Physicians, Philadelphia, March 17, 1960.

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