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J. W. HALLETT, M.D.; M. I. WOLKOWICZ, M.D.; I. H. LEOPOLD, M.D.; E. WIJEWSKI

Arch Ophthalmol. 1960;64(1):133-134.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1922, Meyer¹ reported that the serums of certain patients with rheumatoid arthritis agglutinated sensitized sheep erythrocytes. In 1931, Cecil, Nicholls, and Stainsby² observed the agglutination of β-hemolytic streptococci by the serum of certain patients suffering from rheumatoid arthritis. The suspected etiologic relationship between streptococcal infections and rheumatoid arthritis indicated that the erythrocytes agglutinated because of a precipitin reaction which takes place on the surface of each erythrocyte.³ Because of the variability of preserved sheep erythrocytes Singer and Plotz substituted biologically inert uniform size polystyrene latex particles. With added -globulin and mixed with progressive dilutions of the serum to be tested they devised the latex fixation test for rheumatoid arthritis.³ With this technique they found 71.3% positive reactions in serums from patients afflicted by rheumatoid arthritis.

The association of uveitis with rheumatoid arthritis is well documented. Stanworth and Sharp⁴ found evidence of rheumatoid arthritis in . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Department of Research, Wills Eye Hospital.

Footnotes
Submitted for publication Jan. 27, 1960.

This work was supported in part by a research grant from the national Institutes of Health (BE-1062) U.S. Public Health Service, and the Hartford Foundation.

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