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Part II

BERNARD SCHWARTZ, M.D., Ph.D.

AMA Arch Ophthalmol. 1960;63(4):607-624.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

A closer approach to physiological normalcy can be obtained by using an open system for the culture of the lens.* Certain criteria are necessary to fulfill the definition of an open system. They are (1) a source for a constant supply of nutrient medium; (2) a constant flow of nutrient medium past the lens, and (3) a sink for the collection of the medium. By this method the lens is continually exposed to a fluid of constant composition. The possibility exists therefore that a steady state condition can be obtained in regard to the transport and metabolic rate processes of the lens. With these criteria in mind, the best approach to the design of such an open system appeared to utilize the principle of perfusion.

In order to study the behavior of the lens under simulated in vivo conditions in a perfusion system over a period of several days, . . . [Full Text PDF of this Article]

Author Affiliations
Iowa City

From the Departments of Physiology and Ophthalmology, College of Medicine, State University of Iowa.

Footnotes
Submitted for publication Nov. 23, 1959.

Present address of author: Division of Ophthalmology, Department of Surgery, State University of New York, Downstate Medical Center, Brooklyn 3, N.Y.

Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy, in the Department of Physiology in the Graduate College of the State University of Iowa.

This study was supported in part by a Fight for Sight Award from the National Council to Combat Blindness, Inc., New York and Grant B-1522 from the National Institute of Neurological Diseases and Blindness. It was carried out during a tenure of a Special Clinical Traineeship (BT-322) National Institute of Neurological Diseases and Blindness, United States Public Health Service.

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