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ANTONIO N. FERNANDO, M.D.

AMA Arch Ophthalmol. 1960;63(3):515-539.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

While the changes in ocular tissues in uveitis have been attributed to allergic reactivity, evidence for such an assumption rests on an insecure foundation. Nevertheless, from clinical experiences and investigations it appears highly probable that hypersensitivity does play a significant role in the pathogenesis of the disease.^1,2 The present work is an attempt to use tracer methods in a study of the sequence of events involved in the development of experimental ocular allergic inflammatory reaction in rabbits. Various stages and aspects of this study, such as the fate of the antigen in the eye, in the circulation, its excretion in the urine, appearance of the clinical inflammatory reaction and precipitating antibodies, and the histologic and autoradiographic studies, have been correlated into a composite picture.

Since Nichol and Abt³ induced an iritis in guinea pigs with horse serum, the great majority of subsequent investigators have employed the same . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Ophthalmology, New York University—Bellevue Medical Center.

Footnotes
Submitted for publication Sept. 9, 1959.

These studies were supported by a research grant-in-aid from the Alfred P. Sloan Foundation.

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