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JUBRAN G. MAMO, M.D.; J. NOWAKOWSKI, M.S.; IRVING H. LEOPOLD, M.D.

AMA Arch Ophthalmol. 1960;63(3):510-514.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There is a relatively high concentration of carbonic anhydrase in the avian and mammalian eye,^1,2 as compared with other parts of the body; it appears to be located mainly in the lens and the ciliary body.^1,3-6

A considerable amount of work, evidenced by ample literature, has been directed toward investigating the possible function of this enzyme in the ciliary body.^7-10 The approach has been mainly through the use of carbonic anhydrase inhibitors, studying their effect on aqueous humor flow and ocular tension.^11,12 The role of this enzyme in the formation of aqueous humor is not clearly understood at present.^6,7,13-18

In the lens, where its concentration is about ten times as much as in the ciliary body and iris,^1,6 the function of carbonic anhydrase is far less understood. Tn a recent investigation,¹⁹ great doubt was thrown on any possible function of this enzyme in . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Wills Eye Hospital, Department of Research.

Footnotes
Submitted for publication Sept. 22, 1959.

This investigation was supported by a Research Grant B-693(C)4, National Institute of Neurological Diseases and Blindness, National Institutes of Health.

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