This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Retinal Metabolism in the Alloxan Diabetic Rat

ANDREW de ROETTH, Jr., M.D.; YEN FEN PEI, M.D.

AMA Arch Ophthalmol. 1960;63(2):226-231.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The pathogenesis of diabetic retinopathy remains unknown, partly due to our ignorance of the effect of long-standing diabetes on retinal tissue; for this reason, an experimental approach to this problem seems warranted. In the past¹ the efforts to produce diabetic retinopathy in animals met with only limited success and often the results could not be reproduced. One reason for this failure to obtain retinopathy experimentally was because the animals were killed too soon after the diabetes was produced. Therefore, the purpose of this study was to keep the diabetic animals alive as long as possible in order to simulate the conditions existing in the human eye, since it is well known that the retinopathy develops in patients after diabetes has been present for many years.

In vitro studies^2-7 carried out in a number of tissues of animal origin have shown that diabetes affects certain steps in intermediary . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Ophthalmology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York City.

Footnotes
Submitted for publication Sept. 22, 1959.

This study was supported by Research Grant B-1521 from the National Institute of Neurological Diseases and Blindness, National Institutes of Health, U.S. Public Health Service.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?