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JOSEPH L. HATCH, M.D.

AMA Arch Ophthalmol. 1959;62(4):575-578.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Ochronosis is a rare condition in which eye findings are almost always present.¹ This disease has not been stressed in ophthalmological literature, but its detection is a matter of considerable importance. Skinsnes² reported a tragic case where a man's only eye (the other one was lost after an injury) was needlessly removed because of suspected melanoma of the uvea. This eye had medial and lateral pigmentations of the globe such as are found in ochronosis. No tumor was found. The patient died one year later of bronchopneumonia, and the diagnosis of ochronosis was proved at autopsy.

Hereditary alkaptonuria is characterized by the excretion of homogentisic acid in the urine because of a block in the metabolic breakdown of tyrosine to carbon dioxide and water.

There may be no symptoms, but about one-half of the cases have deposition of Considerable amounts of pigment in the tissues, called ochronosis. . . . [Full Text PDF of this Article]

Author Affiliations
Salt Lake City

From the Department of Ophthalmology, University of Illinois College of Medicine, and the Illinois Eye and Ear Infirmary.

Footnotes
Submitted for publication March 26, 1959.

Presented at a meeting of the Chicago Ophthalmological Society, May 19, 1958.

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