 |
|
The Penetration of C14-Labeled Atropine into the EyeA Comparison of Methods of Application
RALPH G. JANES, Ph.D.;
JAMES F. STILES, B.S.
AMA Arch Ophthalmol. 1959;62(1):69-74.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
Although atropine is one of the oldest drugs known to man and has been widely used as a mydriatic agent, information concerning its penetration into the eye has been gauged, more or less, by the onset of its cycloplegic action and gross effects on the pupil. Two common methods for introducing atropine into the eye are by topical application to the cornea and conjunctiva and by subconjunctival injections.
The passage of drugs through the cornea into the globe is generally considered to be a process of simple diffusion.1 However, since there is a difference in the penetration of chemical compounds with polar and nonpolar constituents there may be an active transport of drugs through the cornea.2 In this transport the pH of the solution seems to be an important factor.3 Identification of chemical compounds after their ingression into the eye has been made in a few instances.
. . . [Full Text PDF of this Article]
Author Affiliations
Iowa City
From the Department of Anatomy, State University of Iowa College of Medicine.
Footnotes
Submitted for publication Dec. 29, 1958.
Thee C14-labeled atropine was supplied by Dr. J. H. Wills, Army Chemical Center, Md.
This work was supported in part by Grant 237, U. S. Public Health Service, and by a "Fight for Sight" summer fellowship, National Council to Combat Blindness, Inc.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
