This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal

RONALD M. WOOD, Ph.D.; MALCOLM W. BICK, M.D.

AMA Arch Ophthalmol. 1959;61(5):709-711.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous communication¹ we confirmed the findings of others^2-4 on the inhibitory effect of heparin on anaphylactic hypersensitivity. The present study was undertaken to explore the role of heparin in the tuberculin type of hypersensitivity, with use of the eye of the rabbit as a convenient site for observing the local reaction elicited by the injection of specific antigen.

Method

Thirty-two normal adult rabbits were infected with a virulent strain of Mycobacterium tuberculosis (var. hominis) by injecting 0.1 ml. of a saline suspension of living organisms into the anterior chamber of the right eyes.

The suspension used for inoculation was standardized so that a 2 mm. platinum loopful, when spread over an area of 1 sq. cm. on a microscope slide, showed an average of 50 organisms per high-power field. The animals developed a progressive tuberculous infection of the inoculated eyes. Three months after infection the animals . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore; Springfield, Mass.

From the Wilmer Ophthalmological Institute of The Johns Hopkins Hospital and University.

Footnotes
Submitted for publication Nov. 10, 1958.

This work was supported in part by a grant (B43C10) from the Department of Health, Education, and Welfare, U. S. Public Health, National Institutes of Health, and in part by a grant from the Knights Templar Eye Foundation Inc.