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JOHN F. SCHMEDTJE, Ph.D.

AMA Arch Ophthalmol. 1959;61(3):453-463.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

If a sterile foreign protein is injected into rabbit vitreous and about two weeks later the same antigen is given intravenously, an acute aseptic inflammatory reaction not only occurs in the uveal tract of the eye into which the material was previously injected but may also occur to less degree in the contralateral eye. These bilateral eye reactions have been experimentally produced and described by Woods,¹ Guillery,² von Szily,³ Marchesani,⁴ Seegal and Seegal,⁵ Schlaegel,^6,7 Foss,⁸ Schlaegel and Wilson,⁹ and Schmedtje.^10,11

Different explanations have been proposed for bilateral eye reactions following the aggravation of only one eye. In the case of the experimentally produced reactions just described in the rabbit, an explanation emphasizing local tissue antibodies was offered by Foss.⁸ He suggested that the original antigen, injected intraocularly, not only sensitizes the cells of the eye into which the material . . . [Full Text PDF of this Article]

Author Affiliations
Boston

Footnotes
Submitted for publication Aug. 4, 1958.

This investigation was begun in the Department of Anatomy, St. Louis University School of Medicine, and completed in the Department of Anatomy, Harvard Medical School.

Early phases of this investigation were presented at the Southern Section of the Association for Research in Ophthalmology, St. Louis, Nov. 10, 1954, and at the American Association of Anatomists, Philadelphia, April 8, 1955.

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