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Report of a Case with Isolation from Aqueous Humor of the Virus in Tissue Culture

ROBERT P. BURNS, M.D.

AMA Arch Ophthalmol. 1959;61(3):376-387.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Cytomegalic inclusion disease or salivary gland virus disease is a pathologic entity that has been known since 1904 by the large intranuclear and intracytoplasmic inclusionbearing cells,¹ but it has recently been emphasized because the etiology has been clarified and its diagnosis has been facilitated by modern techniques. At first it was a pathologic rarity described only at autopsy and diagnosed as congenital syphilis² and amebiasis.³ Later cases were described primarily as erythroblastosis fetalis,⁴ keratomalacia,⁵ whooping cough,^6,7 and toxoplasmosis.⁸

The salivary gland virus was originally described as large inclusion-bearing cells resembling those of cytomegalic inclusion disease found in the salivary glands⁹ in a high percentage¹⁰ of adult animals of numerous species.¹¹ It was found to be associated with a weak species-specific filtrable virus, transmissible to unborn or young animals for a few passages but not to adults,¹² presumably because of . . . [Full Text PDF of this Article]

Author Affiliations
New York

Author's present address: University of Oregon Medical School, Department of Ophthalmology, 3181 S.W. Sam Jackson Park Rd., Portland 1, Oregon.

Footnotes
Submitted for publication Jan. 20, 1958.

This study was aided by a Fight for Sight Award of the National Council to Combat Blindness, Inc., New York.

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