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An Experimental Study

R. H. RIGDON, M.D.; G. L. FELDMAN, M.S.; T. M. FERGUSON, Ph.D.; B. L. REID, Ph.D.; J. R. COUCH, Ph.D.

AMA Arch Ophthalmol. 1959;61(2):249-257.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The first report of a cataract developing in man after the ingestion of dinitrophenol was in 1935.¹ Six years later Horner² collected from the literature 177 cases. The cataracts occurred approximately 15 months after the drug was received.³ Horner,⁴ in 1942, stated, "all attempts to produce experimental cataracts in laboratory animals by various and repeated doses of dinitrophenol have been unsuccessful." Bellows,⁵ in 1944, also commented on the fact that ordinary laboratory animals do not develop cataracts when dinitrophenol is given. Krause⁶ attributed this failure to a difference in the metabolism of the species.

Robbins,^7,8 in 1944, experimentally induced cataracts for the first time in ducklings and chickens by the oral administration of dinitrophenol. He observed a fine gray opacity that progressed to involve most of the anterior portion of the lens. Upon continued feeding the changes in the anterior portion of the . . . [Full Text PDF of this Article]

Author Affiliations
Galveston, Texas; College Station, Texas

Department of Pathology, The University of Texas—Medical Branch (Dr. Rigdon), and Department of Poultry Science, Agricultural and Mechanical College of Texas (Feldman, Ferguson, Reid, and Couch).

Footnotes
Submitted for publication Aug. 5, 1958.

This investigation was supported by research Grants USPH B-1291 and USPH B-1439 from the National Institute of Neurological Diseases and Blindness, U. S. Public Health Service, U. S. Public Health Service Grant-in-Aid B-759.

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