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Penetration of Pyrimethamine (Daraprim) into Ocular Tissues of Rabbits
CHANG S. CHOI, M.D.
AMA Arch Ophthalmol. 1958;60(4):603-611.
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Chemically, pyrimethamine (Daraprim) is 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine, with the empirical formula C12H13N4Cl. This chemical was synthesized by the Wellcome Research Laboratories, Tuckahoe, N. Y., as an antimalarial drug which arrests plasmodial development at those stages involving nuclear division. Besides this antimalarial activity, pyrimethamine has been shown to have an extraordinarily potent antimetabolite activity.
To my limited knowledge, the mode of action of the preparation against toxoplasmosis has not been entirely elucidated. However, Eyles and his associate,1 in 1952, reported antitoxoplasminic action of the drug in mice and, in 1953, showed that pyrimethamine and sulfadiazine were synergistic to each other against experimental toxoplasmosis in the mouse.2 Since these reports, the drug has been widely used in the treatment of presumptive toxoplasmic infections of man as well as of experimental toxoplasmosis of animals.
In the past years, numerous papers on the subject have been published, creating
. . . [Full Text PDF of this Article]
Author Affiliations
Seoul, Korea
Yonsei University, School of Medicine.
Footnotes
Submitted for publication Dec. 16, 1957.
Dr. E. N. Whitman, Burroughs Wellcome & Company, Inc., provided the pyrimethamine powder.
This work was done at the Wills Eye Hospital, Research Department, at the suggestion and under the guidance of Dr. Irving H. Leopold, the Director.
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