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JERRY HART JACOBSON, M.D.; GIDON F. GESTRING

AMA Arch Ophthalmol. 1958;60(2):295-302.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The existence of fibers in the optic nerve which convey efferent impulses from the higher centers to the retina has been a matter of interest and discussion for many years. Histological evidence for these fibers and for the retinal cellular components of such an efferent system has been provided by Dogiel,¹ Cajal,² Johnston,³ and Polyak.⁴ Physiological evidence has been noted by Arey,⁵ who discussed the influence of such elements upon retinal light and dark adaptation. The importance of such a system in dark adaptation has been also mentioned by Pfeifer.⁶ Monakow⁷ described, as a result of animal experiments, the existence of a centrifugal pathway.

Polyak,⁸ more recently, in speaking of "the mechanisms of facilitation or inhibition," states that "a structural arrangement whose function seems to be an interference with the synapses between other neurons is exemplified by the horizontal and centrifugal bipolars . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Division of Electrophysiology, Department of Research, New York Eye and Ear Infirmary and the Albert Einstein College of Medicine, Department of Ophthalmology.

Footnotes
Accepted for publication Jan. 9, 1958.

Seligman Rosenberg, B.A., on a Summer Fellowship of the National Council to Combat Blindness, assisted in this study.

Hexamethonium (Bistrium) used in this study was made available by E. R. Squibb & Sons, Division of Olin Mathieson Chemical Corporation.

Supported by U. S. P. H. S. Grant 1194-B and a grant from the National Council to Combat Blindness and the National Society for the Prevention of Blindness.

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