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RALPH Z. LEVENE, M.D.

AMA Arch Ophthalmol. 1958;59(6):868-872.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The finding that acetazolamide, a potent carbonic anhydrase inhibitor, significantly decreases the aqueous flow rate^2-4,24 has led to the use of this drug as an investigative tool for the further study of the secretory mechanisms. Its mode of action in the eye is subject to controversy. Friedenwald¹¹ and Becker^1,5 favor a local action through the inhibition of carbonic anhydrase in the ciliary body, although other investigators do not subscribe to this view.^13,22,24,31 A study of the effects of the drug on the aqueous and plasma cation concentrations is necessary for a complete understanding of the drug action.

Method

Adult male albino rabbits weighing from 2.5 to 3.5 kg. were utilized, and each eye was used only once for aqueous puncture. They were allowed food (Wayne Rabbit Pellets) and water without restriction. Twenty-four hours before use they were transferred from the regular animal room to an air-conditioned . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Ophthalmology, New York University Post-Graduate Medical School.

Footnotes
Received for publication Sept. 4, 1957.

Acetazolamide was supplied by Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y.

This study was supported by the Ophthalmological Foundation, New York, through a Gustavus and Louise Pfeiffer Research Foundation Grantin-Aid and was undertaken by the investigator on a Fight for Sight Research fellowship from the National Council to Combat Blindness, Inc., New York.

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