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Strychnine, Mescaline, d-Lysergic Acid Diethylamide (LSD), and Atropine

JULIA T. APTER, M.D.

AMA Arch Ophthalmol. 1958;59(5):722-730.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Spontaneous and evoked potentials disappear from the electroretinogram (ERG) within four minutes after enucleation of the eyes of experimental animals (Granit).¹³ An extinguished ERG is also encountered clinically in senile macular degeneration, occlusion of the central retinal vein or artery, and detachment of the retina.^{8,11,18-21,27,28,31} The common factor in these experimental and clinical observations is the dependence of retinal function on an adequate blood supply. Nevertheless, recent reports suggest that the hallucinogenic drugs, mescaline and lysergic acid diethylamide (LSD), potentiate retinal activity despite a reduced blood supply to the retina.

Zádor³⁴ reported that mescaline restored perception of movement in the blind eye of one of his patients with vascular disease. Klüver²² presented evidence that mescaline prolongs the ability of the retina to respond to subliminal stimuli from vascular entoptic phenomena. A single clinical test made in my own laboratory demonstrated that the hallucinogen LSD could . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

Northwestern University School of Medicine, Department of Ophthalmology.

Footnotes
Received for publication Sept. 3, 1957.

This study was supported in part by United States Public Health Service Grant B-1117.

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