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RALPH Z. LEVENE, M.D.

AMA Arch Ophthalmol. 1958;59(4):597-602.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Investigations of the normal osmolar relationship between aqueous and plasma have demonstrated an aqueous osmolar excess in several mammalian species.^8,17,24,25 This excess is considered to be the dominant driving force in aqueous humor formation.^1,16,19 As acetazolamide significantly decreases the aqueous flow rate,^4-6,21 an alteration in the aqueous-to-plasma osmolar relationship might reasonably be expected following the administration of the drug. Urrets-Zavalia and Remedi²⁷ have demonstrated a lowering of the osmolar concentration in the dog aqueous following administration of acetazolamide, on the basis of alterations in electrical conductivity. However, no associated plasma values are reported. The present investigation has been undertaken as a further study of the aqueous-to-plasma osmolar relationship.

Method

Adult male albino rabbits weighing from 2.5 to 3.5 kg. were utilized, and each eye was used only once for aqueous puncture. They were allowed food (Wayne Rabbit Pellets) and water without restriction. Twenty-four hours before use . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Ophthalmology, New York University Post-Graduate Medical School.

Footnotes
Received for publication July 24, 1957.

Acetazolamide was supplied by Lederle Laboratories, Division of American Cyanamid Company, New York.

This study was supported by the Ophthalmological Foundation, New York, through a Gustavus and Louise Pfeiffer Research Foundation Grant-in-Aid and was undertaken by the investigator with a Fight for Sight Research Fellowship from the National Council to Combat Blindness, Inc., New York.

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