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II. The Effects of Lytic Enzymes, Surface-Active Agents, and Urea

H. KARL BOYER, Ph.D.; ANITA A. SURAN, M.S.; M. J. HOGAN, M.D.; W. K. McEWEN, Ph.D.

AMA Arch Ophthalmol. 1958;59(3):333-336.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There have been a number of reports on the modification of the vitreous body by lytic enzymes but few, if any, on the effect of surface-active agents (surfactants) and urea.

In the early work with hyaluronidase, von Sallmann¹ and Pirie² found that this enzyme produced considerable inflammation in the vitreous. Subsequent purification of the hyaluronidase has reduced the amount of inflammation produced. Planten and Hoppenbrouwers,³ using a small amount of hyaluronidase, found little inflammatory reaction after intraocular injection.

A preparation of streptokinase and streptodornase (Varidase) has been studied, with somewhat conflicting results. Jukovsky⁴ claimed that streptokinase-streptodornase produced lysis of blood clots in the anterior chamber of rabbit eyes, while Friedman⁵ found that it produced very little lysis and caused a damaging inflammation. O'Rourke⁶ showed that blood clots were slowly lysed by streptokinase-activated plasminogen and that at concentrations greater than 50,000 units per cubic centimeter . . . [Full Text PDF of this Article]

Author Affiliations
San Francisco

From the Francis I. Proctor Foundation for Research in Ophthalmology, University of California Medical Center.

Footnotes
Received for publication May 27, 1957.

This investigation was supported in part by Contract DA-49-0007-MD-394 of the Department of the Army.

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