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EDWARD TAMLER, M.D.; FRANK C. WINTER, M.D.; PAUL TOCH, M.D.

AMA Arch Ophthalmol. 1957;58(5):647-654.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

For some time now, ophthalmologists have been attempting to save the less involved eye in bilateral retinoblastoma with radiation therapy. The results with x-ray therapy alone have generally been disappointing. Although retinoblastoma is radiosensitive, the dose lethal to the tumor approaches the tolerance of normal structures in the posterior part of the eye and exceeds the tolerance of the structures of the anterior part of the eye.¹ The relatively narrow margin between the cancericidal dose and the dose tolerated by normal ocular tissues has given rise to many complications with x-ray therapy.² The complication of gravest concern is late vitreous hemorrhage from damaged retinal blood vessels.³ In order to reduce the incidence of complications, the dosage of x-ray has been decreased by employing along with it a radiomimetic drug, such as the nitrogen mustards⁴ or, especially, triethylene melamine (TEM).³ The results of this combined therapy . . . [Full Text PDF of this Article]

Author Affiliations
San Francisco

From the Division of Ophthalmology, Department of Surgery (Drs. Tamler and Winter) and Department of Radiology (Dr. Toch), Stanford University School of Medicine.

Footnotes
Received for publication March 22, 1957.

Presented in part at the Western Eye Pathology Society Meeting, San Francisco, Jan. 29, 1957.

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