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PAUL L. CARMICHAEL, M.D., M.Sc.; CAROLINE HAMBLIN, M.S.; HARRY GREEN, Ph.D.; IRVING H. LEOPOLD, M.D., D.Sc.

AMA Arch Ophthalmol. 1957;58(2):169-173.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The recent interest in the role of carbonic anhydrase in the formation of the aqueous humor^1-3 stimulated the present attempt to demonstrate the presence and location of this enzyme in ocular tissues by histochemical methods.

Carbonic anhydrase is known to be a zinccontaining enzyme.⁴ Wistrand⁵ first reported the presence of the enzyme in the anterior uvea of the rabbit. This was confirmed by Green and his co-workers⁶ in 1955, by Ballantine and Maren,⁷ and by Gloster and Perkins⁸ in 1955. These authors employed biochemical techniques in order to demonstrate the presence of carbonic anhydrase.

The demonstration of carbonic anhydrase in histological sections by histochemical methods has been reported by Kurata.⁹ The tissues utilized in the original experiments were the parietal cells of the gastric mucosa and the red blood cells of the rat. A positive reaction was indicated by the deposition of a . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Research Department of Wills Eye Hospital.

Footnotes
Received for publication Jan. 29, 1957.

Supported by a grant from the National Institutes of Health.

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