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Effects of Acetazoleamide

BERNARD BECKER, M.D.

AMA Arch Ophthalmol. 1957;57(6):793-800.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent experimental approaches to the formation of aqueous humor, its composition, and modifications have relied largely on rabbit studies.^1-3 In this species an aqueous humor is formed which is more alkaline and contains an excess of bicarbonate and a deficit of chloride as compared with plasma. These findings tended to support the Friedenwald-Kinsey theories as to the secretion of aqueous humor. Knowledge of the composition of rabbit aqueous and the reported presence of carbonic anhydrase in the ciliary body⁴ led directly to the successful trial of carbonic anhydrase inhibitors, such as acetazoleamide, for suppression of aqueous secretion. In rabbits, tonographic studies revealed that such agents lower intraocular pressure by means of a 50% to 60% suppression of rate of aqueous formation.⁵ Furthermore, the alterations in composition of the aqueous humor of posterior and anterior chamber³ and turnover of test substances⁶ are compatible with this degree . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Department of Ophthalmology, Washington University School of Medicine, and the Oscar Johnson Institute.

Footnotes
Received for publication Jan. 14, 1957.

Presented in part at the Second Conference on Glaucoma of the Josiah Macy, Jr. Foundation, Princeton, N. J., Dec. 4, 1956.

This investigation was supported in part by a research grant, B-621, from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service. The research relating to this study was also financed in part under a grant to Washington University School of Medicine made by the Alfred P. Sloan Foundation, Inc. The grant was made upon recommendation of the Council for Research in Glaucoma and Allied Diseases. Neither the Foundation or the Council assumes any responsibility for the published findings of this study.

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