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V. The Effect of Rapid vs. Gradual Withdrawal from Oxygen on the Mouse Eye

ARNALL PATZ, M.D.; ANN B. EASTHAM

AMA Arch Ophthalmol. 1957;57(5):724-729.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is now generally accepted from abundant clinical^1,2 and experimental^3-5 data that the over-use of oxygen is an important and probably the principal factor in the development of retrolental fibroplasia. There are, however, several controversial factors which are thought to influence the action of oxygen on the premature retina. One of these is the rate of withdrawal from the initial exposure to oxygen. Prolonged gradual withdrawal from oxygen to minimize or avoid the retinal damage produced by oxygen has been advocated principally by Szewczyk⁶ and Bedrossian and co-workers.⁷

This report is based on experiments designed to evaluate the effect of gradual versus rapid withdrawal from oxygen in the mouse eye. The data show that the additional oxygen administered during a period of gradual withdrawal frequently represented that added amount of oxygen necessary to make an initial nontoxic exposure to oxygen injurious.

Subjects and Methods

Experiment I. . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Retrolental Fibroplasia Research Laboratory, District of Columbia General Hospital.

Footnotes
Received for publication Oct. 3, 1956.

Read at the Wilmer Residents Meeting, Baltimore, April 18, 1956.

These studies were aided by grants from the National Institute of Neurological Diseases and Blindness, Public Health Service, and the National Society for the Prevention of Blindness.

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