This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (32)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

DONALD P. TUCKER, M.D.; ARTHUR G. STEINBERG, Ph.D.; DAVID G. COGAN, M.D.

AMA Arch Ophthalmol. 1957;57(4):532-535.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The inheritability of retinoblastoma is a matter of practical concern to the patient and to the physician. In many cases, transmission follows the law of simple Mendelian dominance, and approximately 50% of the offspring of an affected person may be expected to have the disease. In the sporadic cases, that is, in cases of retinoblastoma which appear to occur without preexisting retinoblastoma in the family, the manner of transmission is not so obvious. Yet this information is essential to advise these persons concerning the chances of their offspring having the disease.

This information can be obtained only by analyzing the records of patients with sporadic cases who have had children. Such is the aim of this study. Literature regarding the offspring of patients with carefully documented sporadic cases has been scanty.

Hemmes¹ reported in 1931 four patients with sporadic retinoblastoma with a total of nine offspring, none affected with . . . [Full Text PDF of this Article]

Author Affiliations
Boston; Cleveland; Boston

From the Howe Laboratory of Ophthalmology, Harvard University Medical School. Department of Biology, Western Reserve University.

Footnotes
Received for publication Nov. 12, 1956.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?