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Radioiodine Content of Aqueous, Vitreous, and LensAn Experimental Study in Rabbits
IRVING SHAPIRO, M.D.;
CLIFFORD W. GURNEY, M.D.;
ARTHUR J. SOLARI, M.S.
AMA Arch Ophthalmol. 1957;57(3):430-434.
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Introduction
Radioiodine is one of the important entities in the diagnosis and treatment of thyroid conditions. Greater numbers of patients are receiving increasing amounts of radioiodine. In the treatment of functioning carcinoma of the thyroid the doses of radioiodine being used are large and are steadily being made larger. This study of the penetration of radioiodine to the aqueous, vitreous, and lens of rabbits was undertaken to determine the probability of significant corneal and lenticular damage resulting from the intrinsic radiation inherent in treatment doses of radioiodine.
Methods and Material
Eleven rabbits, five white albino and six brown Flemish giants, weighing between 2.1 and 3.25 kg. were given approximately 4.5 mc. (millicuries) of I131. On the basis of millicuries per kilogram body weight, this approximates the dose which is presently being used in our isotope unit for the treatment of thyroid cancer.
Four of the rabbits were not in a
. . . [Full Text PDF of this Article]
Author Affiliations
Minneapolis; Ann Arbor, Mich.
Department of Ophthalmology (Dr. Shapiro), Department of Internal Medicine (Dr. Gurney), and Department of Radiology (Dr. Solari), University of Michigan, Ann Arbor.
Footnotes
Received for publication Sept. 14, 1956.
This study was supported by the Ophthalmological Research Fund of the University of Michigan.
Read at the East-Central Section of the Association for Research in Ophthalmology, Inc., Toronto, Canada, Jan. 9, 1956.
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