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The Action of Isoflurophate and Homatropine on the Rat's Eye

RALPH G. JANES, Ph.D.; JAMES P. CALKINS, M.D.

AMA Arch Ophthalmol. 1957;57(3):414-417.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The intravenous injection of drugs or their topical application on the eye may produce changes in the ocular blood vessels. However, it has been very difficult to evaluate the action of a particular drug on the vessels, even with the most acute ophthalmoscopic and slit-lamp observations or photographs of the vessels.

Zeller¹ believed that physostigmine might cause either a hyperemia or a constriction of conjunctival vessels. Colle, Duke-Elder, and Duke-Elder² studied the iris vessels with a slit-lamp in animals given intravenous injections of a variety of materials. These investigators used albino rabbits because eye pigment in animals other than albinos obscured the vessels. In general, they could estimate whether a vessel underwent constriction or dilatation. More recently, Leopold and Comroe^3,4 and Von Sallman and Dillon,⁵ studying the effect of topically applied isoflurophate (DFP), suggested that this material caused a dilatation of capillaries as well as arterioles. . . . [Full Text PDF of this Article]

Author Affiliations
Tucson, Ariz.,; Iowa City

From the Departments of Anatomy and Ophthalmology, State University of Iowa, College of Medicine.

Footnotes
Received for publication June 18, 1956.

This work was supported in part by Grant B 237 from the National Institutes of Health, U. S. Public Health Service.

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