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D. R. LUCAS, M.D.; J. P. NEWHOUSE, B.Sc.

AMA Arch Ophthalmol. 1957;57(2):224-235.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In 1951, Brückner described a strain of albino mouse in which the outer nuclear layer of the retina was absent, thus resembling the classical "rodless" strain of Keeler (1924, 1926). Both conditions show a simple recessive mode of inheritance and have been compared with human retinitis pigmentosa. Sorsby, Koller, Attfield, Davey, and Lucas (1954) and Tansley (1954) reported that in Brückner's strain the degeneration of the outer nuclear layer began at about 11 days after birth, while differentiation of the retina was still in progress. Tansley (1934, 1936) had earlier discovered that among normal rats a maternal diet containing not more than 2 β-carotene per day affected the retinae of the sucklings. Growth of the outer limbs of the rods was retarded, and thinning occurred at the junction of the outer and inner limbs. Johnson (1939, 1943) showed that, in young rats fed on a diet highly deficient in . . . [Full Text PDF of this Article]

Author Affiliations
London, England

Footnotes
Received for publication June 18, 1956.

Wernher Group for Research in Ophthalmological Genetics, Medical Research Council, Royal College of Surgeons of England.

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