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ANTHONY DONN, M.D.

AMA Arch Ophthalmol. 1956;56(6):825-829.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Despite the fact that intravenous typhoid vaccine has been used in the treatment of inflammatory diseases of the eye for over 30 years, its mode of action has remained obscure. Many theories have been advanced in an attempt to explain the dramatic benefit which clinicians have observed, in some cases, following typhoid vaccine treatment. However, the underlying mechanism of this treatment is still unknown.

In the past decade, as more information has accumulated concerning the physiology of the adrenal cortex, the assumption has grown among ophthalmologists that typhoid vaccine exerts its beneficial effects by activating the adrenal gland. It is postulated that the injection of typhoid vaccine provides a stressful stimulus and that the pituitary-adrenal axis responds with the release of endogenous adrenocorticosteroids. This assumption is supported by several experimental facts: Intravenous typhoid vaccine has been shown to cause depletion of cholesterol in the adrenal cortex of rats.¹ In . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Institute of Ophthalmology, Presbyterian Hospital, and the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University.

Footnotes
Received for publication May 31, 1956.

Read in part at the Sectional Meeting of the Association for Research in Ophthalmology, Eastern Division, New York, April 28, 1956.

This work is part of a study done in collaboration with Dr. N. P. Christy in the laboratory of Dr. J. W. Jailer, Departments of Medicine and Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University (see Proc. Soc. Exper. Biol. & Med. 91:453, 1956).

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