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A. EDWARD MAUMENEE, M.D.

AMA Arch Ophthalmol. 1956;56(4):557-562.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The term "collagen diseases" was first used by Klemperer¹ to stress the importance of the connective tissue reaction in, and to stimulate investigation of, a group of diseases with heterologous clinical manifestations. The most obvious pathologic feature which is found in each of these diseases is a fibrinoid degeneration of the connective tissue. Neumann,² in 1880, thought that this type of reaction was due to a transformation of the collagen fibers into fibrin-like material. Recently, however, Altshuler and Angevine³ have concluded that the homogenous ground substance, and not the collagen fiber, is the anatomic site of the connective tissue alteration and that the fibrinoid deposits are a result of a precipitation of mucopolysaccharides by the action of a basic protein. Thus, it appears that the term "systemic diseases of the connective tissue" or "dysgammaglobulinemia" is a more appropriate designation than collagen diseases.⁴ However, since the term . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Wilmer Ophthalmological Institute of the Johns Hopkins Hospital and University.

Footnotes
Received for publication April 6, 1956.

Read in the Symposium on Collagen Diseases at the Fifth Pan-American Congress of Ophthalmology, Santiago, Chile, Jan. 9, 1956.

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