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Cooperative Study of Retrolental Fibroplasia and the Use of Oxygen

V. EVERETT KINSEY, Ph.D.; June Twomey Jacobus, B.A.; F. M. Hemphill, Ph.D.

AMA Arch Ophthalmol. 1956;56(4):481-543.

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Introduction

Administration of oxygen to premature infants had been implicated as an etiologic agent in the development of retrolental fibroplasia (RLF) prior to late 1952.* But because of the apparently capricious fluctuation in incidence of the disease observed in various communities and the insufficiency of controlled investigations concerning the possible role of oxygen in RLF the evidence was deemed inadequate to justify curtailment of oxygen for premature infants, particularly in the absence of knowledge of the effect on mortality of such a change in procedure.

For these reasons a number of pediatricians and ophthalmologists agreed early in 1953 to pool their nursery facilities and interests and investigate cooperatively the question of whether oxygen was in fact an etiologic agent in RLF and at the same time to determine what effect restricting oxygen might have on infant mortality. This group of investigators, from 18 hospitals located . . . [Full Text PDF of this Article]

Author Affiliations
Detroit; Detroit; Ann Arbor

From the Kresge Eye Institute (Dr. Kinsey and Mrs. Jacobus) and the Department of Public Health Statistics, School of Public Health, University of Michigan (Dr. Hemphill).

Footnotes
Received for publication July 27, 1956.

The Cooperative Study of Retrolental Fibroplasia was supported in part by a grant from the National Institute for Neurological Diseases and Blindness of the U. S. Public Health Service, Bethesda, Md.; the National Foundation for Eye Research, Boston, and the National Society for the Prevention of Blindness, New York.

The Coordination Committee was composed of the following members: V. Everett Kinsey, Chairman, Kresge Eye Institute; Richard L. Day, State University of New York College of Medicine, Brooklyn; Franklin M. Foote, National Society for the Prevention of Blindness, New York; F. M. Hemphill, School of Public Health, University of Michigan, Ann Arbor; Arnall Patz, Johns Hopkins Hospital, Baltimore; Clement A. Smith, Boston Lying-In Hospital; Harold Tager, U. S. Public Health Service, National Institutes of Health, Bethesda, Md.; F. Howell Wright, Chicago Lying-In Hospital.

The following cooperative hospitals and investigators participated in this study: Abington Memorial Hospital, Abington, Pa.: Theodore S. Wilder, M. Luther Kauffman, Robert M. Shelly; Baltimore City Hospital: Harold E. Harrison, David A. Rosen, Laurence Finberg, Carteret Lawrence; Boston Lying-In Hospital: Clement A. Smith, Julian F. Chisholm Jr., Stewart H. Clifford, Merrill J. King, Murray E. Pendleton; Cooper Hospital, Camden, N. J.: Vincent Del Duca, Ronald M. Bernardin, Harold D. Barnshaw; Chicago Lying-In Hospital: F. Howell Wright, Arlington C. Krause, Albert Dorfman; Michael Reese Hospital, Chicago: Benjamin M. Kagan, Theodore M. Shapira, Julius H. Hess, Alwin C. Rambar, Ralph H. Kunstadter, Harold S. Feinhandler, David S. Kane, Samuel M. Schall, Juan E. Nâvarro; Cincinnati General Hospital: John Fuhs, Daniel V. Jones, Carl A. Koch, Edward A. Wagner; Babies' and Children's Hospital (University Hospitals of Cleveland): John H. Kennell, Anita P. Gilger, Samuel Spector, Robert C. Kirk, Elmer J. Ballintine, Charles Q. McClelland; Children's Hospital, Columbus, Ohio: Thomas E. Shaffer, Morris L. Battles, Arthur M. Culler, Edward W. McCall, Miner W. Seymour, John P. Riepenhoff; Charity Hospital, New Orleans: Ralph V. Platou, James H. Allen, E. Sailors, Elaine Allen, Bonnie Adair, Elaine Fichter, George Ellis, Nelson K. Ordway, George M. Haik, M. J. Tiller, Timoteo Jiménez; Babies' Hospital, New York: William A. Silverman, Algernon B. Reese, Richard L. Day, A. M. Dellaporta, Josef Stepanik; Bellevue Hospital, New York: Jonathan T. Lanman, Loren P. Guy; New York Hospital: Mary Allen Engle, David H. Baker, Irving Baras, Alan Freemond, S. Z. Levine; Hospital of the University of Pennsylvania, Philadelphia: Fred H. Harvie, Harold G. Scheie, Harold S. Medoff, Richard A. Ellis; Pennsylvania Hospital, Philadelphia: Henry F. Lee, M. Luther Kauffman; Temple University Hospital, Philadelphia: Norman Kendall, Glen G. Gibson, Arthur A. Bobb Jr.; Elizabeth Steel Magee Hospital, Pittsburgh: E. R. McCluskey, Robert H. Davies, Murray F. McCaslin; Walter Reed Army Medical Center, Washington, D. C.: Ogden C. Bruton, John H. King Jr., William C. Owens.

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