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LEONARD CHRISTENSEN, M.D.; KENNETH C. SWAN, M.D.; HARRISON D. HUGGINS, M.D.

AMA Arch Ophthalmol. 1956;55(5):666-671.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Formation of nodular excrescences along the pupillary border coincident with pilocarpine and physostigmine therapy was first reported by Vogt in 1920.¹ Except as a medical curiosity, the anomaly received little attention until the advent of more potent miotics. Following introduction of isoflurophate (DFP; di-isopropyl fluorophosphate), Abraham reported a high incidence of these nodules after miotic treatment, particularly in children.* Isoflurophate has been receiving widespread use in the treatment of accommodative esotropia, as well as in the treatment of glaucoma. Swan has reported cases in which the resulting combination of severe miosis and large pupillary nodules temporarily interfered with vision, but generally the nodules have been considered to be transitory and relatively innocuous.⁴ They have been observed to disappear within a few weeks or months after treatment.

Insight into the pathogenesis and nature of the nodules developing during miotic treatment has been largely limited to speculation. From the clinical . . . [Full Text PDF of this Article]

Author Affiliations
Portland, Ore.; Kalispell, Mont.

From the Department of Ophthalmology of the University of Oregon Medical School (Drs. Christensen and Swan).

Footnotes
Received for publication Feb. 8, 1956.

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