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A Comparison of Tonography and Perfusion Measurements In Vivo and In Vitro

BERNARD BECKER, M.D.; MARGUERITE A. CONSTANT, Ph.D.

AMA Arch Ophthalmol. 1956;55(3):305-312.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The perfusion methods of Bárány¹ and Grant² provide a direct experimental approach to the measurement of aqueous outflow in the enucleated eye. When the method is applied to human eyes, opportunities are afforded for comparing in vitro values for facility of outflow with those calculated from tonographic tracings. Such comparison has demonstrated remarkably similar average values for the two populations of normal human eyes.²

The fortunate finding that tonography could be applied to rabbit eyes * permitted comparing the in vitro and in vivo methods in this experimental animal. Furthermore, this comparison could be made more precise by examining the same eye before and after enucleation, thus avoiding individual variation. In addition, the intermediary step before enucleation of perfusion in the living animal has been utilized. The data obtained by such cannulation in the living eye provided additional values for intraocular pressure (P_o), as well as the . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Department of Ophthalmology, Washington University School of Medicine and the Oscar Johnson Institute (Dr. Becker).

Footnotes
Received for publication Jan. 16, 1956.

Presented in part at the Josiah Macy, Jr. Foundation First Conference on Glaucoma, Princeton, N. J., Dec. 7, 1955.

This investigation was supported in part by a research grant, B-621, from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, U. S. Public Health Service.

The research relating to this study was also financed in part under a grant to Washington University School of Medicine made by the Alfred P. Sloan Foundation, Inc. The grant was made upon recommendation of the Council for Research in Glaucoma and Allied Diseases. Neither the Foundation nor the Council assumes any responsibility for the published findings of this study.

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