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Experimental Studies with a Proposed Method of Preparing Sterile Solutions

SIDNEY RIEGELMAN, Ph.D.; DANIEL G. VAUGHAN, Jr., M.D.; MASAO OKUMOTO, M.A.

AMA Arch Ophthalmol. 1955;54(5):725-732.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the past decade many bacteriological studies have been pursued on an in vitro scale in an attempt to evaluate activity of proposed ophthalmic preservatives. These included the work of McPherson and Wood¹; Skolaut²; Scigliano and Skolaut³; Krause, Dauer, and Guth⁴; Heller and associates,⁵ and Murphy, Allen, and Mangiarcine.⁶ It is apparent from these studies that many of the authors consider bacteriostatic concentrations to be a safe level of preservation for these solutions. Murphy, Allen, and Mangiarcine directly stated that bacteriostatic and fungistatic powers were among the properties to be possessed by an ideal ophthalmic preservative. More recently, Lawrence⁷ has published a general review of chemical preservatives for ophthalmic solutions. He concludes:

A careful review of the literature reveals that in preparing and dispensing ophthalmic drugs, chlorobutanol, phenylmercuric nitrate, and benzalkonium chloride are considered the bacteriostatic agents most suitable for providing "self-sterilizing" solutions. . . . [Full Text PDF of this Article]

Author Affiliations
San Francisco

From the University of California Medical Center.

Footnotes
Received for publication Aug. 29, 1955.

This experimental work was done in the Heller and Proctor Laboratories, as a joint project of the School of Pharmacy and the Department of Ophthalmology, University of California Medical Center.

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