This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal

ARTHUR H. KEENEY, M.D.; MANSUKHLAL V. MODY, D.O.M.S.

AMA Arch Ophthalmol. 1955;54(5):665-669.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Adrenochrome is one of the principal oxidation products of epinephrine and has no significant pressor action. It has been studied in Europe since 1937 and in America since 1951 for its action in control of bleeding from capillaries and venules. Its role seems independent of the chemistry of coagulation, the vitamin K-prothrombin mechanism, and the function of heparin or the usual anticoagulants. It is alleged to reduce capillary permeability and to increase capillary resistance,* a statement echoing data in regard to rutin several years ago. Both natural and synthetic adrenochrome are markedly unstable and insoluble. Evolution of the adrenochrome monosemicarbazone sodium salicylate complex has overcome these chemical difficulties. This product is synthetically prepared in America under the trade name Adrenosem and the generic name of carbazochrome.

PREVIOUS REPORT

In an uncontrolled, preliminary report of 69 private patients with bleeding problems, Sherber⁴ found gratifying clinical courses following carbazochrome administration in . . . [Full Text PDF of this Article]

Author Affiliations
Louisville; Surat, India

From the University of Louisville School of Medicine, Section on Ophthalmology.

Footnotes
Submitted for publication Aug. 15, 1955.

These studies were supported in part by a grant from the S. E. Massengill Co., Bristol, Tenn.