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JONAS S. FRIEDENWALD, M.D.; DOLORES RYTEL

AMA Arch Ophthalmol. 1955;53(6):825-831.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Until quite recently a major puzzle in respect to the pathogenesis of radiation cataract has been the long lag period between exposure and the first visible signs of opacification in the lens. Von Sallmann * has shown that mitotic and other nuclear injury in the lens epithelium is an immediate effect of exposure to ionizing radiation, and Cogan³ has found that these injured epithelial cells migrate posteriorly under the lens capsule, thus causing the posterior subcapsular disc-shaped opacity which is so characteristic of radiation cataract. There remains, however, a very large gap in our knowledge, for we have as yet no firm grounds for connecting these epithelial cell changes with the subsequent damage to lens fibers and the development of cortical opacities in the lens. The present study is an attempt to narrow this gap by seeking the earliest recognizable changes in the lens fibers.

The study of the histopathology . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Wilmer Ophthalmological Institute of The Johns Hopkins University and Hospital.

Footnotes
This study was supported by a grant-in-aid from the Atomic Energy Commission.

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