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RUDOLF H. WITMER, M.D.

AMA Arch Ophthalmol. 1955;53(4):547-559.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The results of previous clinical and experimental work with horses suffering from periodic ophthalmia strongly suggest that this uveitis is due to Leptospira pomona and L. grippotyphosa infection,* although the leptospiral nature of periodic ophthalmia could be proved by culture in only a few cases. Hertel³ (1917) produced uveitis in rabbits by injecting suspensions of Leptospira icterohaemorrhagiae into the vitreous and into the anterior chamber. Gsell⁴ reported leptospiral infections in humans, with an occasional involvement of the uvea. These authors did not conduct any serological studies on aqueous humor. Recent experimental data on horses suffering from periodic ophthalmia provided strong evidence of local antibody formation. Similar results were obtained in experimental tuberculous uveitis in rabbits.⁶ Since it has been reported⁵ that rabbits, generally resistant to systemic leptospiral infection, have high antibody titers, this test lesion appeared to be especially suited to the investigation of local antibody . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Footnotes
This investigation was aided by grants of the Knapp Memorial Foundation, the Snyder Ophthalmic Foundation, and the Swiss Academy of Medicine.

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