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HARRY GREEN, Ph.D.; CAROL A. BOCHER, M.S.; IRVING H. LEOPOLD, M.D.; John L. Sawyer; Allen P. Rosenberg, B.S.; Leila P. Waters, A.B.

AMA Arch Ophthalmol. 1955;53(4):472-477.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the preceding paper² evidence was presented that the maintenance of intraocular tension of a normal rabbit eye was not dependent upon the carbonic anhydrase activity of the anterior uvea. The present study was undertaken to determine whether the inhibition of carbonic anhydrase activity of the anterior uvea by the intravenous and subconjunctival administration of acetazoleamide ( Diamox; 2-acetylamino-1,3,4-thiadiazole-5sulfonamide) affected the concentration of bicarbonate ions in the aqueous humor. Our results show that the elaboration and active transfer of bicarbonate ions into the aqueous humor are not mediated by the carbonic anhydrase of the anterior uvea of the normal rabbit eye.

EXPERIMENTAL STUDY

The recent observations of Kinsey³ that the concentration of bicarbonate ions in the posterior chamber of the rabbit eye is not only greater than that in the plasma but also greater than that in the anterior chamber were offered in support of Friedenwald's postulate⁴ that . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Wills Eye Hospital, Department of Research.

Footnotes
A preliminary report has appeared (Green, H., in discussion on Becker1).

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