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Supplemental Testosterone and Estrone in Alloxan Diabetes of the Rat
ARTHUR H. KEENEY, M.D.;
FRED D. BARLOW, M.D.
AMA Arch Ophthalmol. 1955;53(3):407-410.
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Conflicting clinical reports * have recently been published concerning the role of androgens and estrogens in diabetic retinopathy. Unfortunately, neither bioassays nor chemical analyses for tissue levels of these hormones are sufficiently accurate to support the endocrine hypotheses involved. Because of the divergent clinical conclusions and the current impassé in obtaining quantitative hormonal assays, a controlled laboratory study has been undertaken in an experimental diabetic animal. Albino rats rendered diabetic by alloxan were used, it being recognized that retinal vascular changes in the rat, as in most experimental diabetic animals, have been produced only with difficulty, and only in the presence of some additional disturbance or tissue insult. Supplemental estrone was given to one group of diabetic rats in accordance with the hypothesis that this might precipitate additional tissue insult leading to retinopathy. Similarly, testosterone was given to another group on the basis that it might protect against the development of
. . . [Full Text PDF of this Article]
Author Affiliations
Louisville
From the University of Louisville School of Medicine, Section on Ophthalmology.
Footnotes
These studies were supported in part under Grant No. 123 from the Arnold Reuben Fight for Sight Fund of the National Council to Combat Blindness, Inc., New York 19.
Abstract of thesis accepted by the Graduate School of Medicine of the University of Pennsylvania in partial fulfilment of the requirements for the degree of Doctor of Medical Science in Ophthalmology.
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