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HARRY GREEN, Ph.D.; STANLEY A. CAPPER, M.D.; CAROL A. BOCHER, M.S.; IRVING H. LEOPOLD, M.D.

AMA Arch Ophthalmol. 1954;52(5):758-762.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DRAMATIC effect of acetazoleamide (Diamox; 2-acetylamino-1,3,4thiadiazole-5-sulfonamide), a potent carbonic anhydrase inhibitor, in lowering intraocular pressure * has focused attention upon the possible role of the enzyme in the secretory mechanism of the ciliary body and iris. This association is particularly suggestive in view of the report by Wistrand² of the presence of carbonic anhydrase activity in the ciliary body and iris of the rabbit eye. It was deemed of fundamental importance, therefore, to determine whether the administration of acetazoleamide affected the carbonic anhydrase activity of the ciliary body and iris.

METHODS

Carbonic anhydrase activity was measured in a Warburg apparatus at 1 to 2 C. according to the method of Krebs and Roughton.³ The amount of blood in the tissue was determined with the benzidine reaction, according to Ashby and Chan.⁴ Known dilutions of venous blood, drawn from the same rabbit from which the tissue in question . . . [Full Text PDF of this Article]

Author Affiliations
With the Technical Assistance of John L. Sawyer PHILADELPHIA

From the Research Department, the Wills Eye Hospital.

Footnotes
United States Public Health Research Fellow of the National Institute of Neurologic Diseases and Blindness (Dr. Capper).

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