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ANDREW de ROETTH, Jr., M.D.

AMA Arch Ophthalmol. 1954;52(4):571-582.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE OSMOTIC relation between blood and aqueous humor is a factor which plays an important and well-recognized part in governing the intraocular pressure.¹ Duke-Elder² and associates showed in 1938 that the aqueous is slightly hypertonic to blood; this observation was further elaborated by Duke-Elder³ and Davson⁴ and substantiated by Kinsey,⁵ In 1948 Duke-Elder and Davson³ wrote: "It may be that the maintenance of this osmotic gradient is of considerable importance in the mechanism of the intraocular pressure. This factor has not been fully explored." A unified concept for the maintenance of the intraocular pressure was proposed by Kinsey⁶ in 1950; here, again, emphasis was on the osmotic interrelationship of blood and aqueous humor. The attention of the above-mentioned investigators was focused mainly on the intraocular pressure, while other aspects of aqueous humor dynamics were not explored. The introduction of Grant's * aqueous outflow test . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Institute of Ophthalmology, Presbyterian Hospital, and from the Glaucoma Clinic, Institute of Ophthalmology, London; Director of Research, Sir Stewart Duke-Elder.

Footnotes
This study was supported by the Alfred P. Sloan Foundation, Inc., and by the Whitehall Foundation, Inc.

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