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A Clinical Study

IRA A. ABRAHAMSON, Jr., M.D.; PAUL HURWITZ, M.D.

AMA Arch Ophthalmol. 1954;52(4):519-523.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE CONSTANT search for new synthetic mydriatic and cycloplegic drugs as substitutes for homatropine and atropine continues to stimulate the investigator. Most recently, cyclopentylate (Cyclogyl)¹ and its allied chemicals* have met with some degree of success as short-acting cycloplegic replacements for homatropine.

Other similar-acting agents,⁵ whose initial effectiveness proved illusory, have, however, attained limited, though valuable, purposes in the ophthalmological armamentarium. Several such drugs are hydroxyamphetamine (Paredrine), phenylephrine (Neo-Synephrine), eucatropine (Euphthalmine), and Dibutoline.⁶

There is no adequate long-acting synthetic cycloplegic substitute for atropine. Only BL 139⁷ (β-β-diphenyl--dimethylaminovaleramide) approaches the efficacy of atropine in its autonomic ganglion-blocking action and its cycloplegic-mydriatic effect. However, it has not been made available.

Oxyphenonium (Antrenyl), as a potential substitute for atropine, came to our attention during the clinical study of its systemic administration, because of its side-reactions—dryness of the mouth and pupillary dilation. The prolonged cycloplegic and mydriatic action of this . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI; CHICAGO

From the Eye Department of the Cook County Hospital and Chicago Medical School.

Footnotes
The Antrenyl was supplied by Ciba Pharmaceutical Products, Inc., Summit, N. J.

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