This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Potent Atropine Substitute

WILLIAM H. HAVENER, M.D.; HAROLD F. FALLS, M.D.

AMA Arch Ophthalmol. 1954;52(4):515-518.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

OXYPHENONIUM (Antrenyl), a synthetic quaternary ammonium salt (diethyl [2-hydroxyethyl] methylammonium bromide -phenylcyclohexaneglycolate), is a powerful mydriatic and cycloplegic drug. Its anticholinergic pharmacologic effects are essentially the same as those of atropine and are obtainable with approximately the same concentration of drug.¹ Oxyphenonium is stable in tablet or solution and may be administered topically, orally, or parenterally. It is freely soluble in water and almost completely insoluble in nonpolar solvents. Oxyphenonium has been used clinically in the therapy of peptic ulcer and allied digestive disorders² and as a preanesthetic medication.

LABORATORY EVALUATION OF OXYPHENONIUM

Excellent mydriasis, persisting for four to eight days, is produced in adult albino rabbits by a single ocular instillation of one drop of 5% oxyphenonium bromide in 1: 5,000 benzalkonium (Zephiran) chloride. This mydriasis is complete within an hour. A 1% oxyphenonium solution produces complete mydriasis for two days, with return to normal by the . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

Footnotes
Ciba Pharmaceutical Products, Inc., Summit, N. J., supplied the Antrenyl used in this project.

Instructor, Department of Ophthalmology, University of Michigan Medical School (Dr. Havener).

Associate Professor, Department of Ophthalmology, University of Michigan Medical School (Dr. Falls).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?