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YUKIHIKO MITSUI, M.D.; CHIE TANAKA, M.D.; KIICHI YAMASHITA, M.D; JUN HANABUSA, M.D.

AMA Arch Ophthalmol. 1954;52(1):72-76.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A SERIES of trustworthy investigations indicates that distribution of trachoma virus is confined to the epithelial layer of the conjunctiva.* Nevertheless, the significant clinical change in trachoma is subepithelial inflammation, e. g., follicle formation and cellular infiltration. In addition, in the acute stage of infection there is often the association of a preauricular adenopathy. Might these changes not be incurred by a toxin or toxin-like substance produced by the trachoma virus? On the other hand, a toxin or a similar factor has been demonstrated in related viruses, namely, the viruses of psittacosis and lymphogranuloma venereum. The problem as to whether trachoma virus produces a toxin or like substance may, therefore, be worthy of investigation.

DESIGN OF THE EXPERIMENT

Conjunctival matter from trachoma cases with a great number of inclusion bodies no doubt contains trachoma virus in high concentration. If a soluble toxin or toxin-like substance is being produced by the . . . [Full Text PDF of this Article]

Author Affiliations
KUMAMOTO-SHI, JAPAN

From the Department of Ophthalmology, Kumamoto University Medical School.

Footnotes
Supported by the Scientific Research Grant from the Japanese Ministry of Education.

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