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Observations on Virus Inoculation

H. P. KIRBER, M.D.; MARIA WIENER KIRBER, Ph.D.

AMA Arch Ophthalmol. 1953;50(1):2-15.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PRESERVATION of ocular tissues in a living state outside the human body is of interest because such tissues may support the growth of viruses affecting the eye and their mode of action and propagation can be studied. Some viruses have been successfully cultivated in animals or in the developing chick embryo (those of herpes simplex, vaccinia, lymphogranuloma venereum, epidemic keratoconjunctivitis) ; others, such as the viruses of trachoma and inclusion conjunctivitis, have up to now not been grown with certainty outside the human body.

This study deals with experiments in a large series of mammalian ocular tissues transplanted and kept viable on the chorioallantoic membrane of the developing chick embryo and the infection of such transplants with pathogenic ocular viruses.

MATERIALS AND METHODS

In 1912 Murphy¹ successfully grafted mammalian tumor tissues onto the chick embryo. Since then a number of normal and tumor tissues from different species have been . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Children's Hospital ; the Department of Ophthalmology, University of Pennsylvania School of Medicine, and the Department of Bacteriology, Woman's Medical College of Pennsylvania.

Footnotes
This study was supported by grants from the National Council to Combat Blindness, Inc.

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