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R. G. JANES, Ph.D.; G. W. BOUNDS, Jr., M.D.; P. J. LEINFELDER, M.D.

AMA Arch Ophthalmol. 1952;48(4):414-419.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CATARACTS in rats made diabetic by pancreatectomy were observed by Foglia and Cramer¹ in 1944, and in the same year Bailey, Bailey, and Leech² reported cataracts in rats made diabetic with alloxan. Since these earlier studies, many investigators have obtained cataracts in diabetic rats. Most workers have pointed out that high blood sugar levels are imperative for cataract formation. This has been stressed in the recent publications of Sterling and Day³ and Patterson.⁴ By altering experimental diets, mainly by reducing the carbohydrate content, Charalampous and Hegsted⁵ and Rodriguez and Krehl⁶ have prevented cataract formation or delayed its onset in the diabetic rat. Kok-van Alphen⁷ found that if the diabetes in the rat was controlled with insulin, cataract failed to develop. The work cited demonstrates that cataract occurs either because of failure of the lens to metabolize glucose or because the high aqueous sugar . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Departments of Anatomy and Ophthalmology, State University of Iowa College of Medicine.

Footnotes
These studies were aided by grants from the National Council to Combat Blindness upon recommendation of its Medical Consultants and the Central Scientific Funds, State University of Iowa.