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III. Effect of X-Radiation on Mitotic Activity and Nuclear Fragmentation of Lens Epithelium in Normal and Cysteine-Treated Rabbits

LUDWIG VON SALLMANN, M.D.

AMA Arch Ophthalmol. 1952;47(3):305-320.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN RECENT investigations, Buschke, Friedenwald, and associates,¹ and Smelser and Pfeiffer² studied cell division and the influence of ionizing radiations on this function in the corneal epithelium of rats. Mitosis in the lens epithelium has not previously been subjected to comparable investigation, and a few reported figures have given the impression of an extremely low rate of division in this cell layer as a whole.³ The improved technique for preparing total flat mounts of the lens epithelium attached to the anterior portion of the lens capsule, which was worked out recently by Dr. Alma Howard,⁴ provides a means of obtaining reliable estimations of the mitotic index and suggests the possibility of approaching in this way the problem of the effect of radiation on cell division and of testing partial chemical protection against x-ray damage of the mammalian lens.

To these ends the present tripartite study was . . . [Full Text PDF of this Article]

Author Affiliations
With the Technical Assistance of Carmen M. Munoz and Edith Barr NEW YORK

From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Footnotes
The studies on the effect of x-rays on the lens, of which this paper is a part, are based on work performed under Contract #AT-30-1-Gen. 70 of the Atomic Energy Commission.

This study was also supported by the Knapp Memorial Foundation.

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