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ANDREW deROETTH, Jr., M.D.

Arch Ophthal. 1950;43(6):1004-1025.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

BECAUSE of recent advances in the knowledge of the functional importance of cholinesterase, it was considered advisable to investigate this enzyme from the ophthalmologic point of view. The purpose of this paper is to review the literature and to present new experimental data on the activity of cholinesterase in various ocular tissues and fluids, both in the experimental animal and in man.

I. REVIEW OF THE LITERATURE

A. GENERAL LITERATURE

Since Loewi's¹ fundamental discovery in 1921 of a parasympathomimetic substance in the perfusion fluid passed through a dog's heart, literally thousands of papers have been published pertaining to this parasympathomimetic substance—acetylcholine—and its specific enzyme, cholinesterase. The existence of such an enzyme was first demonstrated by Loewi and Navratil,² and the Stedmans,³ in 1932, gave it the present name of cholinesterase. The most important chemical and physiologic characteristics of cholinesterase have been well summarized in several review articles . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Footnotes
Supported by the Knapp Memorial Foundation.

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