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II. Experiments on Disappearance of Red Blood Cells from the Vitreous

LUDWIG VON SALLMANN, M.D.

Arch Ophthal. 1950;43(4):638-652.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EFFECT OF HYALURONIDASE

THE PREVIOUSLY reported experiments on isolated pig and steer vitreous¹ indicated that the decrease of viscosity due to autolytic processes enhanced diffusion of homologous hemoglobin in this substrate. No liquefying or depolymerizing effect of the enzyme hyaluronidase on hyaluronic acid—the viscous component of the vitreous jelly—could be demonstrated by the spreading rate of hemoglobin in fresh steer vitreous. However, these results could not be applied directly to conditions in the living eye of another species. In the first part of the present study the liquefying effect of hyaluronidase was examined on the vitreous of rabbit eyes in vivo. In the main experimental series the effect of the mycolytic enzyme on the disappearance of rat cells from the vitreous was investigated.

TECHNIC

Washed red blood cells served as the test substance in rabbits. A sample of the animal's own blood was withdrawn from the heart or from . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Ophthalmology of Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology of the Presbyterian Hospital in the City of New York.

Footnotes
This study was supported by the Knapp Memorial Foundation.

Read in part before the College of Physicians, Philadelphia, Section on Ophthalmology, March 20, 1947.

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