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ROBERT A. CHAIT, M.D.

Arch Ophthal. 1950;43(3):526-528.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE are many reports of systemic poisoning resulting from the absorption of drugs instilled into the eyes. Symptoms have followed the instillation of cocaine and atropine into the conjunctival sac.

It has not always been certain whether such absorption occurred through the mucous membrane of the conjunctiva or through the nasal mucous membrane after the drug had reached the nose by way of the nasolacrimal duct. Macht¹ ligated or cauterized the nasolacrimal ducts of dogs and was able still to elicit the central actions of morphine and apomorphine after their instillation into the eye. Other drugs studied through their pharmacologic responses in animals² include aconitine, nicotine, potassium cyanide, cocaine, pilocarpine and potassium iodide.

There are no reports in the literature on the absorption of protein through the conjunctival mucosa. It is the purpose of this study to demonstrate, by immunologic means, that unaltered protein may be absorbed through . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Allergy Division of the Jewish Hospital of Brooklyn.

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