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Comparative Clinical Study of Cycloplegic Effects

BERNARD C. GETTES, M.D.

Arch Ophthal. 1950;43(3):446-453.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1944 Swan and White¹ found that certain derivatives of a number of choline esters, rather than possessing a parasympathomimetic action comparable to other choline esters, competed physiologically with the acetylcholine normally present in the body and thus behaved as parasympatholytic drugs. The most promising member of this group appeared to be dibutylcarbamate of dimethylethyl-2-hydroxyethyl ammonium sulfate, which was given the name dibutoline sulfate.

PHARMACOLOGY

Dibutoline sulfate (dibutylcarbamate of dimethylethyl-2-hydroxyethyl ammonium sulfate) is chemically related to carbachol U. S. P. (carbamylcholine chloride; doryl^®) but possesses different physical properties and has antagonistic pharmacologic effects on the intraocular muscles. For example, dibutoline is surface active and mydriatic; carbachol is surface inactive and miotic.

Dibutoline produces paresis of smooth muscles innervated by the parasympathetic nervous system. Its effect on the smooth muscles, therefore, simulates that of paralysis of the oculomotor nerve, that is, . . . [Full Text PDF of this Article]

Author Affiliations
Chief, Refraction Department, Wills Hospital PHILADELPHIA

From the Refraction Department of the Wills Hospital.

Footnotes
Presented at the First Annual Wills Hospital Conference, May 6, 1949. Dibutoline sulfate was made available by Merck & Co., Rahway, N. J.

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