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I. Experiments on Diffusion in the Vitreous and on Permeability of Its Surface Condensation Layer

LUDWIG VON SALLMANN, M.D.

Arch Ophthal. 1949;42(5):583-595.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CLINICAL experience and scattered experimental data indicate that diffusion in the vitreous is slow.¹ These observations were confirmed in systematic studies of Fischer² on diffusion of hemoglobin in arbitrarily divided samples of vitreous and in examinations on spreading of penicillin after intravitreal injection in the living eye.³ New information on this subject was gained by Kinsey, Grant and Cogan⁴ in determining the total movement of vitreous water, with deuterium oxide (heavy water; D²O) as a tracer substance. The authors concluded from their experiments that the movement of water in the rabbit vitreous was of a magnitude of about 85 cu. mm. per minute. Studies on the eye with radioactive sodium (Na²⁴) autographs⁵ provided instructive photographic imprints on diffusion of this normal body constituent in rabbit eyes under physiologic conditions. It was distributed homogeneously throughout the vitreous two to four hours after intraperitoneal . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Ophthalmology, Columbia University College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital.

Footnotes
This study was supported by the Knapp Memorial Foundation.

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